Atheroprone flow activation of the sterol regulatory element binding protein 2 and nod-like receptor protein 3 inflammasome mediates focal atherosclerosis.
نویسندگان
چکیده
Atherosclerosis Athero-Prone Flow Activation of the SREBP2-NLRP3 Inflammasome Mediates Focal Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2013 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation published online July 9, 2013; Circulation. http://circ.ahajournals.org/content/early/2013/07/09/CIRCULATIONAHA.113.004390 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility.
BACKGROUND The molecular basis for the focal nature of atherosclerotic lesions is poorly understood. Here, we explored whether disturbed flow patterns activate an innate immune response to form the NLRP3 inflammasome scaffold in vascular endothelial cells via sterol regulatory element binding protein 2 (SREBP2). METHODS AND RESULTS Oscillatory flow activates SREBP2 and induces NLRP3 inflammas...
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Toll-like receptor-mediated NF-κB activation is a major innate immune reaction of vascular endothelial cells (ECs) in response to prooxidative and proinflammatory stimuli. We identified that TNF-α receptor-associated factor-interacting protein with a forkhead-associated domain (TIFA) is a regulator of priming (signal 1) and activating (signal 2) signals of nucleotide oligomerization domain-like...
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BACKGROUND Oxidative stress activates endothelial innate immunity and disrupts endothelial functions, including endothelial nitric oxide synthase-derived nitric oxide bioavailability. Here, we postulated that oxidative stress induces sterol regulatory element-binding protein 2 (SREBP2) and microRNA-92a (miR-92a), which in turn activate endothelial innate immune response, leading to dysfunctiona...
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Background and purpose: Atherosclerosis is a form of arteriosclerosis that is one of the main causes of death in the world. In coronary artery disease, the vessels are stenosed due to lipid aggregation and inflammation. Epidemiologic studies have shown that in addition to demographic factors such as age and sex, blood pressure, smoking, obesity diabetes and genetics are also associa...
متن کاملActivation of Sterol Regulatory Element Binding Protein and NLRP3 Inflammasome in Atherosclerotic Lesion Development in Diabetic Pigs
BACKGROUND Aberrantly elevated sterol regulatory element binding protein (SREBP), the lipogenic transcription factor, contributes to the development of fatty liver and insulin resistance in animals. Our recent studies have discovered that AMP-activated protein kinase (AMPK) phosphorylates SREBP at Ser-327 and inhibits its activity, represses SREBP-dependent lipogenesis, and thereby ameliorates ...
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ورودعنوان ژورنال:
- Circulation
دوره 128 6 شماره
صفحات -
تاریخ انتشار 2013